This position primarily focuses on the method development and use of LC/MS/MS based in vitro and in vivo assays for PK characterization of our novel drug delivery platform. An essential part of the position is establishing new as well as optimizing the current analytical methods for the quantitative and qualitative measurement of various active pharmaceutical ingredients (APIs) in a variety of biological matrices such as blood, liver, and tumor tissues. This work will include method development, troubleshooting, and routine analyses to support XTuit’s current efforts in building our drug discovery pipeline. The candidate will work closely with the process development and formulation group, as well as our biology and drug discovery group, ensuring a swift progress of ongoing research projects. This position will be based at XTuit’s facility located at the AstraZeneca Biohub in Waltham, MA.
- LC/MS/MS method development and analysis of non-GLP biological samples, planning experiments, troubleshooting and data interpretation
- Sample preparation of biological samples for UPLC/MS/MS analysis
- Maintenance and troubleshooting of LC/MS/MS instrument and sample preparation equipment
- Designing and executing experiments independently with minimal supervision
- Recording, analyzing, and communicating data to team members, including presentations at team meetings
- BS/MS in chemistry, pharmaceutical sciences, or related discipline, and ideally 0-5 years’ experience in the pharmaceutical/biotech industry
- Experience in performing bioanalytical methods and interpreting LC/MS/MS data with comfort in troubleshooting and routine equipment maintenance
- Experience with one or more of the following is desired: LC/MS/MS quantitation of pharmaceuticals, characterization of polymer-drug-conjugates, preparation of biological samples such as plasma, liver tissues, etc.
- Familiarity with Waters Acquity UPLC system and software programs such as Masslynx and/or Empower is a definite plus
- Excellent writing and verbal skills including keen attention to details in authoring and reviewing technical documents
- Strong organizational skills including the ability to manage multiple priorities
- Proficient in Microsoft Office products: Word, Excel, and Outlook
XTuit Pharmaceuticals, Inc. is a biopharmaceutical company developing novel microenvironment-activated therapeutics targeting key disease mechanisms that are responsible for hypoxia, decreased drug uptake, drug resistance, and decreased immune response. The Company’s proprietary drug development pipeline and integrated, sophisticated clinical biomarker platform will be used for accelerated clinical development across selected cancers and fibrotic disorders. XTuit’s compounds act through pleiotropic mechanisms to inhibit extracellular matrix synthesis and stabilization, and to silence activated stromal cells, including cancer-associated fibroblasts and stellate cells. As a result, XTuit compounds alleviate hypoxia and enable enhanced drug uptake through solid stress reduction. Moreover, the drugs have been shown to down-regulate stroma-induced tumor and inflammation signaling pathways to overcome treatment resistance. The Company’s founders include Rakesh K. Jain, Ph.D., Andrew Werk Cook Professor of Tumor Biology (Radiation Oncology) at Harvard Medical School and Director, Edwin L. Steele Laboratory for Tumor Biology at the Massachusetts General Hospital; Robert Langer, Sc.D., David H. Koch Institute Professor at the Massachusetts Institute of Technology; Ronald Evans, Ph.D., March of Dimes Chair in Molecular and Developmental Biology and Professor and Director of the Gene Expression Laboratory at the Salk Institute as well as Howard Hughes Medical Institute Investigator; and Alan Crane of Polaris Partners. XTuit is backed by leading investors, including Polaris Partners, New Enterprise Associates, CTI Life Sciences, Arcus Ventures, and Omega Funds.
We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state, or local protected class.